Thinking too positive? Revisiting current methods of population genetic selection inference.
نویسندگان
چکیده
In the age of next-generation sequencing, the availability of increasing amounts and improved quality of data at decreasing cost ought to allow for a better understanding of how natural selection is shaping the genome than ever before. However, alternative forces, such as demography and background selection (BGS), obscure the footprints of positive selection that we would like to identify. In this review, we illustrate recent developments in this area, and outline a roadmap for improved selection inference. We argue (i) that the development and obligatory use of advanced simulation tools is necessary for improved identification of selected loci, (ii) that genomic information from multiple time points will enhance the power of inference, and (iii) that results from experimental evolution should be utilized to better inform population genomic studies.
منابع مشابه
Comparing the effectiveness of strengthening working memory and critical thinking training on emotion regulation strategies of children with special learning disorder
Abstract Objective: To compare the effectiveness of memory work and critical thinking training of children's movement regulation with special methods. Method: The current research was a semi-experimental research with a pre-test, post-test and control group design. The statistical population included all students aged 9 to 12 who referred to the center for special problems in Tabriz distri...
متن کاملEffects of Linked Selective Sweeps on Demographic Inference and Model Selection.
The availability of large-scale population genomic sequence data has resulted in an explosion in efforts to infer the demographic histories of natural populations across a broad range of organisms. As demographic events alter coalescent genealogies, they leave detectable signatures in patterns of genetic variation within and between populations. Accordingly, a variety of approaches have been de...
متن کاملThe Impact of Contextual Clue Selection on Inference
Linguistic information can be conveyed in the form of speech and written text, but it is the content of the message that is ultimately essential for higher-level processes in language comprehension, such as making inferences and associations between text information and knowledge about the world. Linguistically, inference is the shovel that allows receivers to dig meaning out from the text with...
متن کاملDetecting Directional Selection from the Polymorphism Frequency Spectrum
The distribution of genetic polymorphisms in a population contains information about the mutation rate and the strength of natural selection at a locus. Here, we show that the Poisson Random Field (PRF) method of population-genetic inference suffers from systematic biases that tend to underestimate selection pressures and mutation rates, and that erroneously infer positive selection. These prob...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Trends in genetics : TIG
دوره 30 12 شماره
صفحات -
تاریخ انتشار 2014